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Jianqing Wang, Yan Zhang, Yilu Chen, Min Lin and Zhanglin Lin Global regulator engineering significantly improved Escherichia coli tolerances toward inhibitors of lignocellulosic hydrolysates Biotechnology and Bioengineering 109

Version of Record online: 20 JUN 2012 | DOI: 10.1002/bit.24574

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This work used the global regulator engineering (GRE) approach to obtain mutants of irrE from the radiation-resistant Deinococcus radiodurans which conferred Escherichia coli with markedly enhanced tolerances toward typical inhibitors such as furfural as well as real lignocellulosic hydrolysates. It presents a promising step forward to resolve the hydrolysate inhibitor issue, and suggests the GRE approach can be extended to exploit the exogenous global regulators (e.g., irrE), as well as native ones for eliciting useful phenotypes for industrial microbes.

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