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Geert A.A. Nibourg, Justin D. Boer, Tessa V. van der Hoeven, Mariëtte T. Ackermans, Thomas M. van Gulik, Robert A.F.M. Chamuleau and Ruurdtje Hoekstra Perfusion flow rate substantially contributes to the performance of the HepaRG-AMC-bioartificial liver Biotechnology and Bioengineering 109

Version of Record online: 4 JUL 2012 | DOI: 10.1002/bit.24586

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Nibourg and coworkers used a laboratory version of the AMC-bioartificial liver containing liver cell line HepaRG to test effects of perfusion flow rate through the bioreactor on various hepatic functions and cell damage. The results show that (1) the functionality highly depends on the perfusion rate; (2) there is a universal optimal flow rate; and (3) the mass balance of substrate, metabolite or cell damage markers between in- and out-flow of the bioreactor can only be determined at a suboptimal, low, perfusion rate.

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