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Elissa K. Leonard, Vincent H. Pai, Philip Amberg, Jens Gardner and Elizabeth J. Orwin Design and validation of a corneal bioreactor Biotechnology and Bioengineering 109

Version of Record online: 18 JUL 2012 | DOI: 10.1002/bit.24587

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Physiologically similar mechanical strain can revert cultured cells to a more normal phenotype. In this paper Leonard and coworkers show that 3–7% equibiaxial strain results in favorable protein expression in rabbit corneal fibroblasts, and present a novel bioreactor design capable of imparting strains in this range for corneal tissue culture. In addition to more closely resembling the corneal environment, the system is designed such that cultured tissue can be imaged in real time using optical coherence microscopy.

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