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Stefan Müller, Douglas B. Murray and Rainer Machne A new dynamic model for highly efficient mass transfer in aerated bioreactors and consequences for kLa identification Biotechnology and Bioengineering 109

Article first published online: 25 JUL 2012 | DOI: 10.1002/bit.24594

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Laboratory-scale bioreactors with an efficient aeration system can sustain yeast culture with high cell density and oxygen uptake rate, leading to a significant drop in gas concentration from inflow to outflow. Standard models of gas-liquid mass transfer neglect this gradient and fail to predict the observed dynamics and to identify kLa correctly. A new dynamic model together with dimensionless reactor characteristics provides a theoretical framework that can be readily applied to aerated bioreactors in research and biotechnology.

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