Louisa Gilmore, Stephen Rimmer, Sally L. McArthur, Shweta Mittar, Dachau Sun and Sheila MacNeil Arginine functionalization of hydrogels for heparin binding—a supramolecular approach to developing a pro-angiogenic biomaterial Biotechnology and Bioengineering 110
Development of a pro-angiogenic biomaterial for wound healing and tissue engineering applications is described. Poly(NVP-co-DeGBAC-co-AA) (PNDA) was functionalized with trilysine or triarginine peptides and then used to achieve non-covalent binding of heparin which was then used to bind and release bioactive VEGF. Proliferation of endothelial cells was significantly increased by tri-arginine functionalized hydrogels loaded with heparin and VEGF. Non-covalent interactions between these hydrogels and heparin offer the prospect of these hydrogels being used to bind endogenous heparin in clinical situations.
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