Ashley Slocum, Mike Burnham, Paul Genest, Adith Venkiteshwaran, Dayue Chen and Joseph Hughes Impact of virus preparation quality on parvovirus filter performance Biotechnology and Bioengineering 110
The authors describe excellent performance of a highly purified virus spike, the Ultra 3 parvovirus, on the Viresolve® Pro filter for virus removal processes. The Ultra 3 demonstrates consistently low contaminants with high monodispersal status, and minimal flux decay with 3 different MABs and a polyclonal protein, even when challenged up to 5% spikes. High level spikes could deliver up 8 to 9 logs of virus removed from this processing step that is so critical for most biologics' purification.
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