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Ashley Slocum, Mike Burnham, Paul Genest, Adith Venkiteshwaran, Dayue Chen and Joseph Hughes Impact of virus preparation quality on parvovirus filter performance Biotechnology and Bioengineering 110

Article first published online: 6 AUG 2012 | DOI: 10.1002/bit.24600

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The authors describe excellent performance of a highly purified virus spike, the Ultra 3 parvovirus, on the Viresolve® Pro filter for virus removal processes. The Ultra 3 demonstrates consistently low contaminants with high monodispersal status, and minimal flux decay with 3 different MABs and a polyclonal protein, even when challenged up to 5% spikes. High level spikes could deliver up 8 to 9 logs of virus removed from this processing step that is so critical for most biologics' purification.

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