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Lars Regestein, Heiner Giese, Michael Zavrel and Jochen Büchs Comparison of two methods for designing calorimeters using stirred tank reactors Biotechnology and Bioengineering 110

Version of Record online: 25 JUL 2012 | DOI: 10.1002/bit.24601

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To monitor the biological heat generation in a pilot-scale stirred tank, different reactor designs and modifications are generally conceivable. One approach is based on the determination of the heat transfer coefficient of the reactor system, another one requires the measurement of the mass flow rate of the cooling water. The recalculated biological heat generations based on these two methods were compared and validated by monitoring an Escherichia coli fermentation with an exhaust gas analysis.

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