James Pollock, Sa V. Ho and Suzanne S. Farid Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty Biotechnology and Bioengineering 110
This paper evaluates the current and future potential of batch and continuous cell culture technologies via a case study based on the commercial manufacture of monoclonal antibodies. The case study compares fed-batch culture to two perfusion technologies: spin-filter perfusion and an emerging perfusion technology utilizing alternating tangential flow (ATF) perfusion. The strategies were compared across a range of scales and titres so as to visualize how their ranking changes in different industry scenarios.
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