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Peng-Yuan Wang, Tsung-Han Wu, Pen-Hsiu Grace Chao, Wei-Hsuan Kuo, Meng-Jiy Wang, Cheng-Che Hsu and Wei-Bor Tsai Modulation of cell attachment and collagen production of anterior cruciate ligament cells via submicron grooves/ridges structures with different cell affinity Biotechnology and Bioengineering 110

Article first published online: 10 AUG 2012 | DOI: 10.1002/bit.24615

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Anterior cruciate ligament (ACL) cells were harvested from porcine knee and cultured on the grooved surfaces with various feature sizes and surface chemistries. Cell alignment is feature size-dependent, while type I collagen production is both feature size- and surface chemistry-dependent on the grooved surfaces. This study demonstrates that grooved topography accompanied by favorable surface chemistry facilitates ACL tissue engineering.

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