Sarah L. Davies, Clare S. Lovelady, Rhian K. Grainger, Andrew J. Racher, Robert J. Young and David C. James Functional heterogeneity and heritability in CHO cell populations Biotechnology and Bioengineering 110
This study reveals that despite the inherent genetic instability of CHO cells in functionally heterogeneous parental populations, it is practically possible to exploit this intrinsic variability to obtain clonal derivatives that exhibit heritable differences in key functional attributes that can impact biomanufacturing processes. Davies and coworkers demonstrate that clonal derivatives can be obtained with a rapid biomass accumulation phenotype that performs better than the functionally heterogeneous donor parental cell population.
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