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Ilaria E. Palamà, Stefania D'Amone, Addolorata M.L. Coluccia and Giuseppe Gigli Micropatterned polyelectrolyte nanofilms promote alignment and myogenic differentiation of C2C12 cells in standard growth media Biotechnology and Bioengineering 110

Article first published online: 16 AUG 2012 | DOI: 10.1002/bit.24626

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The authors have combined a layer-by-layer polyelectrolyte multilayer deposition with a micro-molding in capillaries (MIMIC) method to simultaneously provide biochemical and geometrical instructive cues that induced the formation of tightly apposed and parallel arrays of differentiating myotubes from C2C12 cells maintained in GM media for 15 days.

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