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Rainer Gross, Katja Buehler and Andreas Schmid Engineered catalytic biofilms for continuous large scale production of n-octanol and (S)-styrene oxide Biotechnology and Bioengineering 110

Article first published online: 10 DEC 2012 | DOI: 10.1002/bit.24629

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This study evaluates the technical feasibility for continuous large scale production of fine chemicals, such as n-octanol and (S)-styrene oxide, with engineered catalytic biofilms. Based on results obtained in a micro-scale membrane reactor for the here described selective alkane hydroxylation and a previously reported asymmetric styrene epoxidation, process parameters for a 1,000 tons/year production scale are presented. The results indicate that this biofilm application can be a sustainable alternative compared to traditional suspended cells processes in terms of product yield and biomass waste production.

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