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Jorge Almodóvar, Justin Mower, Apurba Banerjee, Ajoy K. Sarkar, Nicole P. Ehrhart and Matt J. Kipper Chitosan-heparin polyelectrolyte multilayers on cortical bone: Periosteum-mimetic, cytophilic, antibacterial coatings Biotechnology and Bioengineering 110

Version of Record online: 1 SEP 2012 | DOI: 10.1002/bit.24710

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The surface of devitalized cortical bone is modified with chitosan-heparin polyelectrolyte multilayers. These biomimetic periosteum coatings are characterized spectroscopically, and shown to support the adhesion and proliferation of mesenchymal stem cells, while suppressing both Gram positive (S. aureus) and Gram negative (E. coli) bacteria. These coatings have potential as synthetic periosteum to improve the outcomes of cortical bone allografts.

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