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Apoorv Gupta, Jessica L. Terrell, Rohan Fernandes, Matthew B. Dowling, Gregory F. Payne, Srinivasa R. Raghavan and William E. Bentley Encapsulated fusion protein confers “sense and respond” activity to chitosan–alginate capsules to manipulate bacterial quorum sensing Biotechnology and Bioengineering 110

Version of Record online: 18 SEP 2012 | DOI: 10.1002/bit.24711

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Chitosan–alginate capsules were formed and subsequently loaded with an AI-2 synthase “nanofactory” to modulate QS activity in Escherichia coli. We propose that biologically inspired carriers of molecular synthesis systems in native settings can modulate bacterial populations, including those of the human microbiome.

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