Georges Sabra and Patrick Vermette A 3D cell culture system: Separation distance between INS-1 cell and endothelial cell monolayers co-cultured in fibrin influences INS-1 cells insulin secretion Biotechnology and Bioengineering 110
A three-dimensional in vitro cell culture chamber was designed, built using micro-fabrication techniques and validated. This cell culture system allowed study of the effect of separation distance between monolayers of rat insulinoma cells (INS-1) and human umbilical vein endothelial cells (HUVEC) co-cultured in fibrin over INS-1 cells insulin secretion. Sabra and Vermette report the importance of the separation distance between two cell niches for cell culture design and the possibility to enhance beta cells function.
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