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Juan Antonio Tamayo-Ramos, Sharief Barends, Dennis de Lange, Annemarie de Jel, Raymond Verhaert and Leo de Graaff Enhanced production of Aspergillus niger laccase-like multicopper oxidases through mRNA optimization of the glucoamylase expression system Biotechnology and Bioengineering 110

Article first published online: 20 SEP 2012 | DOI: 10.1002/bit.24723

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A high throughput method for the screening and selection of Aspergillus niger transformants expressing high yields of five recombinant laccase-like multicopper oxidases was used to assess the effect of different mRNA 5′ untranslated regions (5′UTRs) in extracellular protein production. The results obtained show that modifications in the 5′UTR of the widely used A. niger glaA expression system can lead to improvements in protein yields.

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