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Justin Weaver, Scott M. Husson, Louise Murphy and S. Ranil Wickramasinghe Anion exchange membrane adsorbers for flow-through polishing steps: Part II. Virus, host cell protein, DNA clearance, and antibody recovery Biotechnology and Bioengineering 110

Version of Record online: 11 OCT 2012 | DOI: 10.1002/bit.24724

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Anion exchange membrane adsorbers are used in the biopharmaceutical industry for clearance of host cell proteins, DNA and viruses. While the effectiveness of primary amine based ligands is not compromised at high ionic strength, the presence of hydrogen phosphate ions leads to reduced capacity. Monoclonal antibody recovery using primary amine based anion-exchange ligands may be lower if significant binding occurs due to secondary interactions. The removal of a specific contaminant is affected by the level of removal of the other contaminants.

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