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Sahng Ha Lee, Yong-Chan Kwon, Dong-Myung Kim and Chan Beum Park Cytochrome P450-catalyzed O-dealkylation coupled with photochemical NADPH regeneration Biotechnology and Bioengineering 110

Version of Record online: 5 OCT 2012 | DOI: 10.1002/bit.24729

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Cytochrome P450 monooxygenases are multi-functional enzymes with widespread applications in chemoenzymatic synthesis of complex chemicals as well as in studies of metabolism and xenobiotics. Lee and coworkers performed a visible light-driven photoenzymatic O-dealkylation reaction by using a cell-free synthesized P450 BM3 monooxygenase variant (BM3m2). A sustainable photoenzymatic reaction of the P450 BM3 was performed through visible light-driven regeneration of NADPH from NADPH. The P450 biocatalysis, coupled with photochemical cofactor regeneration, suggests an excellent strategy for visible a light-driven selective oxidation reaction.

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