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Ana Rita Brochado and Kiran R. Patil Overexpression of O-methyltransferase leads to improved vanillin production in baker's yeast only when complemented with model-guided network engineering Biotechnology and Bioengineering 110

Version of Record online: 23 OCT 2012 | DOI: 10.1002/bit.24731

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Overexpressing enzymes from a heterologous de novo vanillin biosynthesis pathway in baker's yeast leads to increased vanillin production only when combined with model-guided metabolic engineering. This study illustrates how the production of valuable chemicals can be improved through a synergistic approach, which combines metabolic engineering strategies emerging from both local pathway-based and global network-based analyses.

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