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Julia J. Mack, Abigail A. Corrin, Sergio L. dos Santos e Lucato, James C.Y. Dunn, Benjamin W. Wu and Brian N. Cox Enhanced cell viability via strain stimulus and fluid flow in magnetically actuated scaffolds Biotechnology and Bioengineering 110

Article first published online: 11 OCT 2012 | DOI: 10.1002/bit.24736

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A non-contact actuation system was used to explore the effects of strain stimulus on the proliferation and spatial distribution of smooth muscle cells in tubular scaffolds. Magnetically actuable scaffolds were fabricated by winding electrospun sheets of a biodegradable polymer functionalized with magnetic nanoparticles. The tubular scaffolds were actuated by a magnetic field to induce a cyclic crimping deformation, which applies strain stimulus to the cells and pumps nutrient fluid through the porous tube walls.

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