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Suhyung Cho, Bo-Rahm Lee, Byung-Kwan Cho, June-Hyung Kim and Byung-Gee Kim In vitro selection of sialic acid specific RNA aptamer and its application to the rapid sensing of sialic acid modified sugars Biotechnology and Bioengineering 110

Article first published online: 5 NOV 2012 | DOI: 10.1002/bit.24737

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The RNA aptamer showing high affinity and specificity against N-acetyl neuraminic acid, the most common member of sialic acids, was screened and engineered to the aptazyme by coupling with the ribozyme. The aptazyme displayed distinguishable activity to the sialic acid modified sugars from other sugars without the tedious process such as releasing from linked sugars, purification, and modification. This work may be very useful for the diagnosis and the rapid sensing of sialic acid modified molecules.

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