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Yan Zhu, Jiangning Song, Zixiang Xu, Jibin Sun, Yanping Zhang, Yin Li and Yanhe Ma Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis Biotechnology and Bioengineering 110

Article first published online: 18 OCT 2012 | DOI: 10.1002/bit.24739

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A novel optimization method TOS was developed to calculate the thermodynamically optimal solution, based on the energy conservation, the second law of thermodynamics, the minimum magnitude of the Gibbs free energy change and the maximum entropy production principle (MEPP). TOS was applied to five physiological conditions of E. coli and the resulting prediction accuracy was found significantly improved (10.7–48.5%), indicating that TOS can be considered an advanced calculation and prediction tool in metabolic engineering.

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