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Ryan B. Huang, Anjelica L. Gonzalez and Omolola Eniola-Adefeso Laminar shear stress elicit distinct endothelial cell e-selectin expression pattern via TNFα and IL-1β activation Biotechnology and Bioengineering 110

Article first published online: 18 OCT 2012 | DOI: 10.1002/bit.24746

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Naïve or shear-preconditioned endothelial cell (EC) monolayers were exposed to TNFα or IL-1β in static or in the presence of high laminar shear. Simultaneous presence of shear generally enhanced E-selectin expression relative to static activation in naïve ECs in response to either TNFα or IL-1β stimulation. Prior exposure to shear preconditioning mutes E-selectin expression with shear-TNFα activation, while enhancing or down-regulating shear-IL-1b induced expression, dependent on the activation period.

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