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K. Höffner, S. M. Harwood and P. I. Barton A reliable simulator for dynamic flux balance analysis Biotechnology and Bioengineering 110

Version of Record online: 18 OCT 2012 | DOI: 10.1002/bit.24748

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Dynamic flux balance analysis (DFBA) provides a platform for detailed design, control and optimization of biochemical process technologies. The numerical tool presented here accurately and efficiently simulates large-scale dynamic flux balance models. The main advantages of this approach are that the linear program only has to be solved when qualitative changes in the optimal flux distribution of the metabolic network occur and that it can reliably simulate behavior near the boundary of the domain where the model is defined.

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