Rita Lencastre Fernandes, Magnus Carlquist, Luisa Lundin, Anna-Lena Heins, Abhishek Dutta, Søren J. Sørensen, Anker D. Jensen, Ingmar Nopens, Anna Eliasson Lantz and Krist V. Gernaey Cell mass and cell cycle dynamics of an asynchronous budding yeast population: Experimental observations, flow cytometry data analysis, and multi-scale modeling Biotechnology and Bioengineering 110
In this paper, the experimentally observed dynamics of cell size and cell cycle position distributions, for a batch cultivation of Saccharomyces cerevisiae, are described using a 2-stage population balance model (PBM). Furthermore, the segregated model is coupled to a simple kinetic model describing the varying extracellular environment. The good agreement between the model predictions and the experimental observations confirms the potential of using PBM for describing dynamic microbial populations, subject to a changing extracellular environment.
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