Ying Yang, Jianzhou Li, Xiaoping Pan, Pengcheng Zhou, Xiaopeng Yu, Hongcui Cao, Yingjie Wang and Lanjuan Li Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system Biotechnology and Bioengineering 110
In this study, the authors developed a novel liver cell co-culture system. C3A cells were co-cultured with human placental mesenchymal stem cells (hPMSC) in microspheres placed in a fluidized bioreactor. Their results suggest that this culture system significantly improved the preservation of liver cells'metabolic functions which may greatly enhance the efficacy of bioartificial liver treatment.
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