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Wenjie Sun, Antonia Luna-Velasco, Reyes Sierra-Alvarez and Jim A. Field Assessing protein oxidation by inorganic nanoparticles with enzyme-linked immunosorbent assay (ELISA) Biotechnology and Bioengineering 110

Version of Record online: 1 NOV 2012 | DOI: 10.1002/bit.24754

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Increased application of engineered nanoparticles (NPs) has given rise to concerns about their toxic effects to biological systems. This study assessed the feasibility of utilizing an enzyme-linked immunosorbent assay (ELISA) to measure protein oxidation caused by NPs. The mechanisms involved in the protein oxidation by the reactive NPs (Mn2O3, Cu(0), CuO and Fe(0)) could be attributed to the combined effects of ROS-dependent and direct protein oxidation, providing insights on NP toxicity mechanisms.

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