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Miriam S. Mann and Tina Lütke-Eversloh Thiolase engineering for enhanced butanol production in Clostridium acetobutylicum Biotechnology and Bioengineering 110

Version of Record online: 1 NOV 2012 | DOI: 10.1002/bit.24758

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A new combinatorial metabolic engineering approach to optimize biosynthetic pathways involving thiolase-dependent carbon flux limitations was developed. This strategy was employed to engineer the thiolase of Clostridium acetobutylicum for reduced sensitivity towards its physiological inhibitor, free coenzyme A, and expression of the optimized thiolase derivative was demonstrated to increase clostridial butanol production.

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