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Stefano Menegatti, Mahmud Hussain, Amith D. Naik, Ruben G. Carbonell and Balaji M. Rao mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands Biotechnology and Bioengineering 110

Version of Record online: 19 NOV 2012 | DOI: 10.1002/bit.24760

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A novel method is presented for the synthesis of mRNA-display libraries of cyclic peptides by reversible library adsorption and solid-phase peptide cyclization. Peptide ligands identified through library screening have been used to purify immunoglobulins from cell culture supernatants with high yield and purity. The approach presented herein can be used to generate and evaluate cyclic peptide affinity ligands for a broad spectrum of targets.

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