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Guoyou Huang, Senhao Wang, Xiang He, Xiaohui Zhang, Tian Jian Lu and Feng Xu Helical spring template fabrication of cell-laden microfluidic hydrogels for tissue engineering Biotechnology and Bioengineering 110

Version of Record online: 12 NOV 2012 | DOI: 10.1002/bit.24764

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This work developed a simple method to fabricate microfluidic hydrogels with helical microchannels based on a helical spring template. Results from both experimental investigation and numerical modeling revealed a significant enhancement on the perfusion ability and cell viability of helical microfluidic hydrogels compared to those with straight microchannels. The feasibility of such a helical spring template method was also demonstrated for microfluidic hydrogels with complex three-dimensional channel networks such as branched helical microchannels.

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