Oliver Hardick, Stewart Dods, Bob Stevens and Daniel G. Bracewell Nanofiber adsorbents for high productivity downstream processing Biotechnology and Bioengineering 110
Electrospun polymeric nanofibers offer a possible solution to limited productivity in downstream processing. Here the authors fabricate cellulosic nanofibers functionalized with DEAE ligands. These are packed into a cartridge to promote flow distribution and convective mass transfer. The resultant material is resilient to fouling and can be operated at high flowrates while maintaining capacity. These excellent mass transfer properties offer significant productivity improvements (potentially 10 fold) if combined with continuous chromatography.
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