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Pranay Ghosh, Kaveh Vahedipour, Min Lin, Jens H. Vogel, Charles A. Haynes and Eric von Lieres Zonal rate model for axial and radial flow membrane chromatography. Part I: Knowledge transfer across operating conditions and scales Biotechnology and Bioengineering 110

Version of Record online: 23 NOV 2012 | DOI: 10.1002/bit.24771

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The zonal rate model (ZRM) approach is extended from axial to radial flow configurations. Membrane chromatography capsules at different scales are analyzed under binding and non-binding conditions. The ZRM can help saving valuable material and time, as the experiments required for model calibration are much cheaper than the predicted large-scale experiments at binding conditions.

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