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Shahana Safdar, Courtney A. Payne, Nam H. Tu and Lakeshia J. Taite Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O6-Methylguanine-DNA Methyltransferase activity Biotechnology and Bioengineering 110

Article first published online: 23 NOV 2012 | DOI: 10.1002/bit.24775

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Glioma-specific NO donors were used to induced chemosensitivity in vitro. Cell viability of T98G and U-87MG malignant glioma cells is significantly decreased and levels of active MGMT and p53 are implicated in the mechanism of chemoresistance. Cell invasion is also decreased through the occupation of MMP-2 on glioma cell surfaces.

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