Lars Kober, Christoph Zehe and Juergen Bode Optimized signal peptides for the development of high expressing CHO cell lines Biotechnology and Bioengineering 110
Highly productive cell lines are required for the production of biopharmaceutical products. To this end a variety of signal peptides was used to express different antibodies and non-antibody products in transiently and stably transfected Chinese hamster ovary (CHO) cells. Thereby it could be demonstrated that signal peptide B, but also signal peptide E can be used to generate cell lines with cell specific productivities (QP) up to 60 or 90 pg antibody/cell/day (pcd mean values are represented by red bars).
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