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Lars Kober, Christoph Zehe and Juergen Bode Optimized signal peptides for the development of high expressing CHO cell lines Biotechnology and Bioengineering 110

Version of Record online: 17 JAN 2013 | DOI: 10.1002/bit.24776

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Highly productive cell lines are required for the production of biopharmaceutical products. To this end a variety of signal peptides was used to express different antibodies and non-antibody products in transiently and stably transfected Chinese hamster ovary (CHO) cells. Thereby it could be demonstrated that signal peptide B, but also signal peptide E can be used to generate cell lines with cell specific productivities (QP) up to 60 or 90 pg antibody/cell/day (pcd mean values are represented by red bars).

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