T.J. Spencer, L.A. Hidalgo-Bastida, S.H. Cartmell, I. Halliday and C.M. Care In silico multi-scale model of transport and dynamic seeding in a bone tissue engineering perfusion bioreactor Biotechnology and Bioengineering 110
A mathematical model predicting the coupled fluid flow, mass transport and cell seeded attachment in a perfusion bioreactor for a bone tissue engineering application is developed and proposed. Model boundary conditions derive directly from microCT scans of the porous PLLA scaffold and bioreactor vessel enabling both small scale and large scale flow features with out resort to approximation. The models use for in silico design is thus demonstrated.
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