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David Bulnes-Abundis, Leydi M. Carrillo-Cocom, Diana Aráiz-Hernández, Alfonso García-Ulloa, Marisa Granados-Pastor, Pamela B. Sánchez-Arreola, Gayathree Murugappan and Mario M. Alvarez A simple eccentric stirred tank mini-bioreactor: Mixing characterization and mammalian cell culture experiments Biotechnology and Bioengineering 110

Version of Record online: 26 NOV 2012 | DOI: 10.1002/bit.24780

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The authors study the mixing performance and mammalian cell culture adequacy of a 30 mL eccentric stirred tank mini-bioreactor. A detailed mixing characterization of the proposed bioreactor is presented. Their results demonstrate good mixing performance. Mammalian cell culture experiments were conducted. Relevant biological indicators of CHO cell cultures grown in the mini-bioreactor were comparable to those observed in 1 L-fully instrumented bioreactors. Human hematopoietic stem cells were successfully expanded 10-fold using the eccentric system.

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