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Russell P. Wolfe and Tabassum Ahsan Shear stress during early embryonic stem cell differentiation promotes hematopoietic and endothelial phenotypes Biotechnology and Bioengineering 110

Version of Record online: 15 FEB 2013 | DOI: 10.1002/bit.24782

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Application of shear stress during ESC differentiation in a 2D system is a robust method for promoting endothelial and hematopoietic phenotypes. Responses were similar for a range of stress magnitudes and different protein-coated surfaces. These effects, however, were dependent on the duration and time point of treatment exposure and required activation of the FLK1 protein. These results suggest that shear stress in microcarrier-based scalable systems may be one approach to generate the necessary number of cells needed for therapeutic applications.

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