Rui Yao, Renji Zhang, Feng Lin and Jie Luan Biomimetic injectable HUVEC-adipocytes/collagen/alginate microsphere co-cultures for adipose tissue engineering Biotechnology and Bioengineering 110
Biomimetic microtissues composed of surface-coated adipocyte/collagen/alginate microspheres and HUVECs co-cultures were developed in this paper. These co-cultures contained both a tissue element and a vascularization element and highly resembled the components, distribution and structure of natural adipose tissue. Subcutaneous injection into the node mice suggested vascularized adipose tissue formation with functional anastomosis and long-term stability of volume and weight, indicating that the vasculature formed within the constructs benefited the formation, maturity and maintenance of adipose tissue.
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