Roya R.R. Sardari, Tarek Dishisha, Sang-Hyun Pyo and Rajni Hatti-Kaul Improved production of 3-hydroxypropionaldehyde by complex formation with bisulfite during biotransformation of glycerol Biotechnology and Bioengineering 110
3-Hydroxypropionaldehyde (3HPA) was produced from glycerol by Lactobacillus reuteri through a single enzyme catalyzed reaction. Complex formation with sodium bisulfite was studied and used for in situ capture of 3HPA in a fed-batch biotransformation, with prolonged bioactivity of the cells for at least 18 h and more than double yield of 3HPA than the process without bisulfite. The ratio of 3HPA to other products was also doubled.
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