Harini G. Sundararaghavan, Randi L. Saunders, Daniel A. Hammer and Jason A. Burdick Fiber alignment directs cell motility over chemotactic gradients Biotechnology and Bioengineering 110
A major hurdle in utilizing tissue engineered scaffolds in vivo is the lack of cell infiltration and angiogenesis in implanted materials. The authors investigated competing influences of chemical factors and topographical cues (aligned fibers) on endothelial cell migration. Though chemical cues are the most common method used to direct cell migration, the authors found topographical cues are more influential, and overlaying these cues compounds their effects.
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