Kathy Y. Wei, Yvonne Y. Chen and Christina D. Smolke A yeast-based rapid prototype platform for gene control elements in mammalian cells Biotechnology and Bioengineering 110
Most existing gene-control systems are either mechanistically specific for microbial organisms or must be laboriously re-engineered to function in mammalian cells. The authors demonstrate a ribozyme-based device platform where devices prototyped in yeast to regulate gene expression can be directly transported to mammalian cells. Their unique device architecture acts as a rapid prototyping platform (RPP) based on a yeast chassis, providing a genetically tractable system that supports high-throughput screens for generating gene-controllers functional in mammalian cells.
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