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Jieyu Zhang, Koon Gee Neoh, Xuefeng Hu, En-Tang Kang and Wilson Wang Combined effects of direct current stimulation and immobilized BMP-2 for enhancement of osteogenesis Biotechnology and Bioengineering 110

Version of Record online: 29 DEC 2012 | DOI: 10.1002/bit.24796

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Electrical stimulation (ES) can accelerate bone fracture healing, but the implanted metal electrodes may cause adverse effects. Herein, the authors propose a strategy to replace the metal electrodes with a biodegradable, electrically conductive film comprising polypyrrole nanoparticles and chitosan, and functionalized with bone morphogenetic protein-2 (BMP-2). Osteoblasts cultured on this BMP-2-functionalized film and subjected to ES exhibited a twofold increase in mineralization over the control group (i.e., without immobilized BMP-2 and ES) after 21 days.

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