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Yvonne E. Thomassen, Aart G. van 't Oever, Marian Vinke, Arjen Spiekstra, René H. Wijffels, Leo A. van der Pol and Wilfried A.M. Bakker Scale-down of the inactivated polio vaccine production process Biotechnology and Bioengineering 110

Version of Record online: 29 DEC 2012 | DOI: 10.1002/bit.24798

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An up-to-date lab-scale version encompassing the legacy inactivated polio vaccine production process was set-up. The production process, consisting of Vero cell culture, poliovirus culture, the subsequent purification using filtration and chromatography units and inactivation procedure was scaled-down. The followed approach was initial scale-down of the separate unit operations at setpoint and subsequent, application of the unit operations successively in a comparative manner to large-scale manufacturing. With this scale-down model representative trivalent vaccine can be made.

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