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Tony Chen, Matthew J. Hilton, Edward B. Brown, Michael J. Zuscik and Hani A. Awad Engineering superficial zone features in tissue engineered cartilage Biotechnology and Bioengineering 110

Version of Record online: 27 DEC 2012 | DOI: 10.1002/bit.24799

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A major challenge in cartilage tissue engineering is reproducing the native extracellular matrix anisotropy. This study uses a hydrodynamic rotating bioreactor to mimic aspects of the flow fields produced during joint sliding and characterizes the effect of these hydrodynamic fields on the anisotropy of tissue engineered cartilage hydrogels and the production of surface zone specific matrix proteins and structural alignment.

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