E-mail

E-mail a Wiley Online Library Link

Matthew D. Wood, Tessa Gordon, Stephen W.P. Kemp, Edward H. Liu, Howard Kim, Molly S. Shoichet and Gregory H. Borschel Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair Biotechnology and Bioengineering 110

Version of Record online: 4 JAN 2013 | DOI: 10.1002/bit.24800

Thumbnail image of graphical abstract

Bioengineering strategies to promote peripheral nerve regeneration after injury tend to focus on therapies to bridge large nerve defects with fewer therapies developed to treat other nerve injuries, such as delayed repair following nerve transection. The authors constructed delivery systems using fibrin gels containing either free GDNF or polylactide–glycolic acid (PLGA) microspheres with GDNF to treat delayed nerve repair. GDNF microspheres improved axonal regeneration and functional motor outcomes, such as improved contractile muscle force and preservation of muscle mass.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH