Matthew D. Wood, Tessa Gordon, Stephen W.P. Kemp, Edward H. Liu, Howard Kim, Molly S. Shoichet and Gregory H. Borschel Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair Biotechnology and Bioengineering 110
Bioengineering strategies to promote peripheral nerve regeneration after injury tend to focus on therapies to bridge large nerve defects with fewer therapies developed to treat other nerve injuries, such as delayed repair following nerve transection. The authors constructed delivery systems using fibrin gels containing either free GDNF or polylactide–glycolic acid (PLGA) microspheres with GDNF to treat delayed nerve repair. GDNF microspheres improved axonal regeneration and functional motor outcomes, such as improved contractile muscle force and preservation of muscle mass.
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