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Vincent E.G. Diederich, Peter Studer, Anita Kern, Marco Lattuada, Giuseppe Storti, Ram I. Sharma, Jess G. Snedeker and Massimo Morbidelli Bioactive polyacrylamide hydrogels with gradients in mechanical stiffness Biotechnology and Bioengineering 110

Version of Record online: 4 JAN 2013 | DOI: 10.1002/bit.24810

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A technique for the preparation of polyacrylamide hydrogels with a gradient in Young's modulus from 150 kPa down to 20 kPa within a length of 10 mm, is presented. Upon surface treatment with collagen I, the produced hydrogels are bioactive and human foreskin fibroblasts feel the strength of the underlying material. After 2 hours, HFFs on the soft end of the sample are still round and small, while they are already well spread on the stiff end of the substrate.

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