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Payel Datta, Robert J. Linhardt and Susan T. Sharfstein An 'omics approach towards CHO cell engineering Biotechnology and Bioengineering 110

Version of Record online: 4 FEB 2013 | DOI: 10.1002/bit.24841

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Chinese hamster ovary(CHO) cells have been extensively utilized for industrial production of biopharmaceuticals. The sequencing of the CHO genome has provided new avenues for CHO cell engineering to improve productivity, increase robustness, and permit production of novel bioproducts. This review details advances in the use of 'omics technologies to gain fundamental understanding of CHO cell physiology and improve CHO-cell engineering.

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