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Stephanie Duncanson and Athanassios Sambanis Dual factor delivery of CXCL12 and Exendin-4 for improved survival and function of encapsulated beta cells under hypoxic conditions Biotechnology and Bioengineering 110

Version of Record online: 26 MAR 2013 | DOI: 10.1002/bit.24872

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A promising treatment for diabetes is a bioartifical pancreas. However, graft failure occurs, in part due to hypoxic conditions at the transplant site. CXCL12 and GLP-1 have been shown to have anti-apoptotic effects on beta cells, and additionally GLP-1 has insulinotropic effects. In this study, the authors found that presentation of CXCL12 in combination with delivery of Exendin-4 (Ex-4), a GLP-1 analog, significantly reduced beta-cell apoptosis and increased insulin secretion under hypoxic conditions.

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