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Jae Seong Lee, Tae Kwang Ha, Jin Hyoung Park and Gyun Min Lee Anti-cell death engineering of CHO cells: Co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction Biotechnology and Bioengineering 110

Article first published online: 16 MAR 2013 | DOI: 10.1002/bit.24879

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In order to achieve a more efficient protection of cells from stressful culture conditions, the simultaneous targeting of anti-apoptosis and pro-autophagy in CHO cells was attempted by co-overexpressing an anti-apoptotic protein, Bcl-2, and a key regulator of autophagy pathway, Beclin-1, respectively. This approach achieved a more efficient inhibition of cell death and a longer culture period, providing the evidence that pro-autophagy engineering together with anti-apoptosis engineering yields a synergistic effect and successfully enhances the anti-cell death engineering of CHO cells.

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